DON WHITLEY SCIENTIFIC – THE LEADING INTERNATIONAL SUPPLIER TO THE MICROBIOLOGY AND TISSUE CULTURE INDUSTRIES


Contact Us +44 (0) 1274 595728 sales@dwscientific.co.uk

Follow Don Whitley Scientific

Posts Tagged ‘H35 HEPA Hypoxystations’

Whitley i2 Instrument Workstation in use

Whitley Workstations Used in Novel Research Approach to Neurodegenerative Disorders

Efficient energy production is primarily driven by oxygen and is crucial in the brain, which consumes 20% of the body’s total energy whilst weighing only 2% of the total body weight. Loss of oxygen in the brain (hypoxia) can result in brain damage, which can contribute to dementia including Alzheimer’s disease (AD) and can influence amyotrophic lateral sclerosis (ALS, commonly known as motor neuron disease) disease mechanisms. Those mechanisms are often poorly understood, however, the cellular consequence of hypoxia including disruptions to energy supply are often observed in the brains of patients with these neurodegenerative disorders. The ability to model a hypoxic environment and study the effects on AD and ALS in the laboratory has historically been limited by the lack of available technology.

The SITraN laboratory takes the gold standard approach for measuring the effect of hypoxia on energy generating pathways in cells by using an XF metabolic bioanalyser (which measures energy generation in a non-invasive manner in cells, Seahorse Bioscience/Agilent), housed within an i2 Instrument Workstation and H35 HEPA Hypoxystation. The i2 chamber has been designed specifically to house and run metabolic flux assays using the XF bioanalyser in a hypoxic environment. The H35 section of the chamber is HEPA filtered and gas, temperature and humidity controlled allowing us to perform cell manipulation on our ALS and AD cell models.

Using this novel combination of technologies – SITraN aims to measure how hypoxia affects the energy generating pathways in brain cells. Their novel approach will allow the identification of the pathways involved in the cell response to hypoxia, which lead to energy disruption in patients with AD and ALS and will allow therapeutic hypoxic markers of disease to be identified for future clinical studies.

Article provided by Dr Scott Allen, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield. 

Dr Allen will be presenting at the ALS/MND Symposium in Glasgow held from 7-9 December 2018.

New Whitley Hypoxystation Video Launched

Don Whitley Scientific are proud to present a new video that showcases our wide range of Whitley Hypoxic Workstations. The video also features comments from renowned researchers, explaining how a Whitley Hypoxystation benefits their research.

The video is another addition to a growing YouTube channel which features similar videos showcasing our wide product range and company values, including anaerobic and microaerobic workstations, customer testimonials, an introduction to Don Whitley Scientific and the level of service on offer for our customers.

 

 


Researchers featured in this video
Dr Karen Wright – Dr Karen Wright uses a Whitley H35 Hypoxystation in the cell culture laboratory at Lancaster University to expedite a component of her research, namely culturing human gut cells at low physiological levels of oxygen. – Testimonial in full

Dr Michael Cross – Dr Cross and his group use their H35 HEPA Hypoxystation to test cardiovascular drug toxicity in a cardiac spheroid model under physiologically relevant oxygen tensions and also periods of extreme hypoxia/ischemia. – Testimonial in full

 

Click here to explore the full range of Whitley Hypoxystations

 



Contact our sales team for more information on 01274 595728 or email sales@dwscientific.co.uk. For the full range of Whitley products, visit our website at www.dwscientific.co.uk