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Archive for September, 2015

Biomedical Scientist_Clinical Microbiology of Anaerobes Course

Australian Workstation users could be entitled to $500

Do you use a Whitley Workstation? You could be entitled for a grant of up to $500

Our travel grant scheme, which covers the use of any Whitley Workstation or Hypoxystation, is also available to Workstation users in Australia. This means if you have used a Whitley Workstation and cited its use on your poster or in a published paper, contact us and you could be eligible for a grant of up to $500.

A range of grants are available for those who mention the use of a Whitley Workstation or Hypoxystation in a published paper or a poster they are going to present. All we ask for in return is a copy of the paper/poster in which the workstation features. We will use this on our website and in other ways to help us promote the Whitley Workstation range.

Also, if Don Whitley Scientific are exhibiting at the event where you are presenting your poster, we can provide copies of the document to all who visit our stand, if this is something you would like us to do.

To apply for this grant, please send a copy of your poster or paper along with your contact details to If you are presenting a poster at an event, don’t forget to let us know the name of the event and the date you will be delivering your presentation.

Technical Sales Representative Required

Technical Sales Representative Required

40 years on and Don Whitley Scientific is still expanding. We now seek a Technical Sales Representative for the southern region of the UK to promote our exciting range of capital laboratory equipment and service contracts into numerous sectors, including clinical, research and industrial.

If you are interested in applying for the position and would like more information, please email for a full job specification or click here.


Two important upcoming SfAM meetings

Here’s news of two meetings being held by the Society for Applied Microbiology.

The first of these SfAM meetings, scheduled for 13th of October, is IMPACT – The Early Career Scientists Research conference. The aim of this conference is to offer guidance on how aspiring scientists can make an impact in their chosen field. “This year’s ECS conference aims to shed some light on methods of scientific impact, with a panel discussion featuring microbiologists specialising in social media, policy, journal, media and academia.” The conference offers a fantastic opportunity to network for early career scientists and early career microbiologists, with the SfAM Environmental Microbiology Lecture following the event. Click here for more information on this event.

The second event is scheduled for 7th of December and is the Antimicrobial Resistance Meeting with the theme of Prevention, Containment and Control. The aim of the meeting is to tackle the growing concerns regarding tackling AMR, concerns which have been shared by the British Prime Minister, David Cameron, when he said that a failure of action now will lead to an “almost unthinkable scenario where antibiotics no longer work and we are cast back into the dark ages of medicine”. Click here for more information on this event. 

Both of the events will be held at the Royal Society of Medicine in London.




















Are your cells holding their breath?

Are your cells holding their breath?

The hypoxic microenvironment exerts a significant influence on the epigenetic regulation of stem cell fate and behavior in vivo, and the role of low oxygen in maintenance and differentiation of stem cells in culture is coming under intense scrutiny. Epigenetic responsiveness to environmental cues in the cell environment to optimize gene expression can be modulated through chromatin or histone modification, transcriptional co-regulators and methylation/demethylation sequences (Tsai & Wu, 2014). The pathways regulating stem cell behavior are particularly interesting in the light of regenerative therapies, and oxygen level has been shown by many groups to be a master determinant of both pluripotency and differentiation. Hypoxia can, for example, induce microRNA’s that target the 3’ untranslated region of histone deacetylases, driving embryonic stem cells to differentiate into the myogenic lineage (Lee et al, 2015). Transcriptional activation of anti-angiogenesis genes during hypoxia as mediated by epigenetic changes in methylation patterns influences the status of stem cell-like populations in tumors (Ueda et al., 2014).

One of our Hypoxystation users, Brad Wouters at Princess Margaret Cancer Centre in Toronto, examines how epigenetic modifications are coordinated in response to local tumor microenvironment. His work has provided insights into the acquisition of a stem-cell phenotype in breast cancer through H3K27m3-mediated repression of the DICER promotor, reduced miRNA processing, and de-repression of ZEB1 transcription factors, resulting in hypoxia-induced EMT (Van den Beucken, 2014). Elizabeth Koch in the Toronto lab recently presented her results, obtained in the Hypoxystation, at the 14th International Wolfsberg Meeting on Molecular Radiation Biology & Oncology in Switzerland (images shown here).

Research into the epigenetic regulation of stem cell behavior and fate benefits from a more physiological culture environment as provided by an hypoxia workstation. The Hypoxystation by Don Whitley Scientific mimics those physiological conditions in a closed workstation atmosphere, tightly controlling oxygen, carbon dioxide, temperature and humidity for the duration of your cell culture. Visit us at the Cell Symposium on “Stem Cell Epigenetics” in Sitges, Spain from September 20-22 to experience the Hypoxystation for yourself. Your cells are holding their breath!




This article was written by Burga Kalz Fuller of HypOxygen

Literature on epigenetic regulation of stem cell fate at hypoxia:

Van den Beucken et al (2014) “Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER” Nature Communications 5:5203

Tsai and Wu (2014) “Epigenetic regulation of hypoxia-responsive gene expression: focusing on chromatin and DNA modifications.”Epigenetic regulation Int. J. Cancer 134, 249-256

Lee at al (2015) “MicroRNA-26a induced by hypoxia targets HDAC6 in myogenic differentiation of embryonic stem cells” Nucl. Acids Res. 43 (4): 2057-2073

Ueda et al (2014) “The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth” Mol. Cell Biol. 34(19): 3702-3720



Thackley Storm start the season in style

Under 16’s football team, Thackley Storm, recently beat local rivals Bingley Juniors a whopping 5-1, starting a new season in fantastic fashion.

It was a strong performance from the Storm, who made up for a disappointing season last year with a comprehensive victory over previous bogey team, Bingley Juniors. Thackley Storm went into the half time break 3-0 up and didn’t relent in the second half, putting two more past the Bingley keeper. This win means Thackley Storm start the season with 3 points that put them at the top of the Craven, Aire & Wharfe Junior League.

Thackley Storm Under 16’s football team, proudly sponsored by Don Whitley Scientific, are next in action in two weeks time with a cup game against Salts Tigers.


Automatic Sleeve Gassing on Whitley Workstations

A feature unique to Whitley Workstations is the option to evacuate and gas sleeves automatically. With one touch of the footswitch, sleeves can be filled and evacuated with ease, maintaining workstation conditions and avoiding any potential disturbance to your work through operator error.

Some users are not confident in using the vacuum and gassing feature on sleeves. Automatic sleeve gassing ensures sleeves are correctly vacuumed and filled with gas before the users hands are introduced into the chamber. Once the routine has been completed, there is no need to re-gas the sleeves until the next time you enter the workstation. This automatic sleeve gassing system is available on most Whitley Workstations.



  • Maintain a cost effective strategy for gas use
  • Avoid disturbance to workstation conditions
  • Reduce the risk of operator error
  • Unique to Don Whitley Scientific Workstations


sleeves1 sleeves2



















Society for Applied Microbiology

SfAM Antimicrobial Resistance Meeting


 7 December 2015 | 09:00 – 17:00

Royal Society of Medicine, 1 Wimpole Street, London, UK


The Society for Applied Microbiology (SfAM) presents a meeting to look at AMR from clinical (medical and veterinary), environmental and economic viewpoints and ask the question: are we doing enough to prevent the predicted scenario of being “cast back into the dark ages of medicine”?

This meeting gathers prominent stakeholders from government, funding agencies, pharma and academia to discuss the current efforts in tackling AMR.

David Cameron, UK Prime Minister echoed the thoughts of many world leaders and scientists when he said that a failure of action now will lead to an “almost unthinkable scenario where antibiotics no longer work and we are cast back into the dark ages of medicine”.

This one-day conference presents solutions and updates on AMR through keynote speakers, case studies, presentations, expert opinion and a panel discussion and invites you to join in the AMR conversation.



09:00 – 09:30 Tea, coffee, exhibition and registration

09:30 – 09:35 Chairman’s welcome

09:35 – 10:15 Where we are now. Tim Walsh, Cardiff University, UK

10:15 – 10:45 The O’Neill Review – what is the economic impact of AMR? Anthony McDonnell, O’Neill Review, UK

10:45 – 11:15 Environmental resistance. Will Gaze, University of Exeter, UK

11:15 – 11:45 CPE, CRE, CPO and CRABs. Jon Otter, Kings College London, UK

11.45 – 12.35 Panel Discussion – will we be cast back into the dark ages of medicine?

12:35 – 14:00 Lunch and exhibition

14:00 – 14:30 Clinician’s view. Vanya Gant, University College Hospital, UK

14:30 – 15:00 Vet’s view. Tim Potter and Matt Dobbs, Westpoint Farm Vets, UK

15:00 – 15:30 AMR in companion animals. Nicola Williams, University of Liverpool, UK

15:30 – 16:00 Future prospects. Katie Hopkins, Public Health England, UK

16:00 – 17:00 Tea, coffee, exhibition and networking


The bookings page and programme for this event can be accessed through Registration closes on 23 November 2015.

For further information, contact Sally Hawkes by email: or phone: +44 (0)1933 382191