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Tissue Culture

 

TEB1000 Master UnitTEB1000 Tissue Engineering System

A new concept in 3D tissue engineering

The TEB1000 Flow Bioreactor provides the ideal conditions for growing and developing tissue cultures under accurately controlled flow conditions. It has the functionality of a CO2 incubator but incorporates an integrated double peristaltic pumping system. It features a digital control system with touchscreen interface for ease of use. This Master Unit can be used to work with an unlimited number of tissues, conditions and biomaterials to extend the range of experiments possible.

The tissue culture package for use in the Master Unit consists of P3D disposable culture chambers and racking systems that allow scientists to grow cells on porous scaffolds under perfusion conditions. This system also allows for the seeding and culture of scaffolds in the same chamber, minimising the risk of contamination.

READ A TESTIMONIAL FROM AN EMINENT SCIENTIST AT THE UNIVERSITY OF ZARAGOZA BELOW ...

P3D disposable chamber P3D Racking System P3D perfusion system set-up

P3D disposable chamber

Example of a racking system

Example of a perfusion system set-up

                                       

 A vascular package, which allows the growth of cells on tube-shaped scaffolds, is also available with reusable, glass culture chambers designed to be used with vessels, stents and grafts of different lengths and diameters.

Given the breadth of research in tissue culture, it may be that this package does not entirely meet your needs. In such a case, please do give us a call as we can customise some elements to provide you with the perfect solution.

Contact us today to discuss your application and see how these products could help you.

Whitley H35 HypoxystationNeed to strictly control oxygen and other parameters in your work? We also manufacture and supply the Hypoxystation range of products, designed specifically for tissue culture research where the ability to create normoxic, hypoxic and anoxic conditions within a controlled and sustained environment is crucial. For more information, please see http://www.dwscientific.co.uk/hypoxia_anoxia.php


Read here how the TEB1000 Bioreactor has been helping one scientist ....

"Our main research topics are Mechanobiology and Regenerative Medicine (Tissue Engineering). Related to Mechanobiology, we are now studying the effect of the shear stress in the hMSC behaviour. Thanks to the TEB1000 from Ebers we able now to apply different shear stress ratios to our cells in a 2D chamber. We are studying the cell migration, proliferation, differentiation and also the CSK reorganization.
 
In the field of Regenerative Medicine, we have focused our interest in two different approaches. One related with Cell Therapy and the other with Tissue Engineering. In our Cell Therapy approach, we are trying to stimulate mechanically the homing and the engraftment of hMSC for vardiovascular ischaemic diseases. In this case, we are using the TEB1000 Master Unit to stimulate the hMSC with different shear stress ratios prior to being injected in animal models.
 
In relation to Tissue Engineering we have focused our interest in different topics. We are interested in the application of mechanical stimuli to induce differentiation of stem cells and also to achieve a better matrix deposition. Our tissue of interest in this case is the cartilage, where it is well known that a mechanical stimulation is able to improve the results obtained in static studies. Again, the TEB1000 bioreactor allows us to stimulate the polymeric scaffolds where we have seeded our cells.
 
We have also recently started a new research line related with the tissue decellularization. We have been able to decelullarize different organs like heart, lung, esophagus, liver, etc. but the main interesting thing is that thanks to the special seeding program of the TEB1000 we have been able to recelullarize various organs in a very efficient way and also provide fresh nutrients in every moment to the newly seeded cells. This study is very preliminary but also very promising."
 
 
Provided by:
Ignacio Ochoa Garrido,
Biomedical Research Networking center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)
Aragón Institute of Engineering Research (I3A), Group of Structural Mechanics and Materials Modelling (GEMM)
University of Zaragoza