DON WHITLEY SCIENTIFIC – THE LEADING INTERNATIONAL SUPPLIER TO THE MICROBIOLOGY AND TISSUE CULTURE INDUSTRIES


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Archive for August, 2018

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Poldip2 governs cellular metabolism under hypoxic conditions

Until recently, it was understood that the addition of the prosthetic group lipoate is essential to the activity of critical mitochondrial catabolic enzymes; however, its regulation was unknown. In their paper “Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer“, Paredes et al. prove that the Poldip2-controled lipoylation of αKDH and PDH is regulated under hypoxia and in cancer cells, most notably in triple negative breast cancer cells (TNBC).

Using a Don Whitley Scientific  H35 Hypoxystation to establish accurate hypoxic environments, the authors were able to manipulate Poldip2 expression, allowing them to make substantial contributions to the understanding of Poldip2’s essential role in metabolic function during both normoxic and hypoxic conditions. Additionally, they postulate that Poldip2 deficiency may specifically impact the fate and availability of Ac-CoA due to impaired TCA cycle function, potentially providing cancer cells with an advantage for cell proliferation or hypertrophy. Further research will require investigating the interplay between Poldip2 and HIF-1α as well as the regulation of Poldip2 expression at different oxygen concentrations – a task easily achievable thanks to the Hypoxystation’s intuitive interface for effortlessly adjusting the gas composition.

The Whitley  Hypoxystation provides the user with incredible flexibility as it can control oxygen down to 0.1% while providing a temperature and humidity controlled environment with ample working space. The atmosphere is constantly monitored and adjusted by the real-time feedback system to ensure accuracy.

 

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Supporting the Scientific Community

As well as manufacturing and supplying equipment for microbiology and cell culture applications worldwide, Don Whitley Scientific also makes an extensive effort to support the scientific community. For several years we have supported science through various means, these are listed below.

 

 

 

Workstation Poster Grant

If you have used a Whitley Workstation or Hypoxystation in your work and have mentioned it in your poster or published paper, let us know and you could be entitled to a grant of £250. All we ask in return is a copy of your poster/paper so we can use it on our website to help promote the range to others. Payment will be made in good faith after receipt and approval of the draft poster/paper to enable you to travel to the event to present it.

To apply for this grant, please send a copy of your draft poster or paper along with your contact details to steve_robertson@dwscientific.co.uk. If you are presenting a poster at an event, don’t forget to let us know the title of the event and the date you will be making your presentation.

 

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Picture of Helen Inns in The Mould That Changed the World

The Mould That Changed the World

Don Whitley Scientific has some very talented customers, not least Leeds Biomedical Scientist, Helen Inns. Helen is usually to be found at the WASPLab, working with bacteria including MRSA and Carbapenemase-Producing Enterobacteriaceae. This month, instead of just looking for “Superbugs”, she’s making a song and dance about them – at the Edinburgh Fringe in a show called The Mould That Changed The World.

Helen is part of a chorus of healthcare professionals performing in the world premiere of a brand-new musical, called The Mould That Changed the World. The show is a fun educational production which tells the story of Fleming’s discovery of penicillin, the development of antibiotics, and the looming crisis of antimicrobial resistance which now threatens healthcare as we know it.

Banner ad for The Mould that Changed the World

The Mould That Changed the World is receiving rave reviews at the Edinburgh Fringe, where it’s showing daily until 25th August.

After that, a free resource pack will be available, so primary schools can put on their own production and empower children to learn about and spread the message of antimicrobial stewardship.

Follow on Facebook and Twitter:  https://www.facebook.com/mouldchangedtheworld/

https://twitter.com/ThatMould

Find out more, or sign up for the schools production, at www.mouldthatchangedtheworld.com

 

 

wasp_lab_to be at Microbe 2018

Visit Don Whitley Scientific at Microbe 2018 and win a prize

 

Are you booked to attend this year’s Microbe in Sheffield? If you are, call at the Don Whitley Scientific stand to see WASPLab, ChromaZona and Whitley Workstations. There are also prizes to be won!

 

WASPLab

At what promises to be another entertaining, interesting, informative event, Don Whitley Scientific will showcase WASPLab. This is the complete robotic specimen processing system – including versatile software that conducts multiple plate scans during incubation, enabling early detection of positive growth. It provides the ability to perform antibiotic sensitivity testing; sub-culture work; and links to the MALDI-TOF identification system.

CHROMAZONA Automatic Colony Counter


ChromaZona

We will also be showing ChromaZona, the automated microbial identification and AST analysis system for faster results – and to EUCAST standards – in  busy clinical laboratories.

Whitley Workstations

Whitley A35 Anaerobic Workstation

Whitley A35 Workstation

If you need ideal conditions for the processing, incubation and examination of anaerobes and microaerophiles, come and discover the range of Whitley Workstations and the new Catalyst Monitoring System.

For more information

And if you are not able to attend Microbe this year but would like information on any of these products (or to discuss others in the Whitley range), please visit our website at www.dwscientific.co.uk or contact our sales office on sales@dwscientific.co.uk or call 01274 595728.