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Archive for July, 2016

CHROMAZONA Automatic Colony Counter

Chromazona colony counter launched

Chromazona is a new automated colony counter, manufactured by Synbiosis. It is an automated microbial identification and antibiotic susceptibility testing (AST) analysis system that will lead to faster results in busy clinical laboratories. Chromazona can be used to generate objective, repeatable, traceable data in double-quick time and to EUCAST standards.

Chromazona is an IVD certified instrument that:

  • Features a sensitive CCD camera, unique lighting system and powerful Chromogenic ID software to provide identification of microbial species in seconds.
  • Automatically reads different plate types up to 150mm diameter.
  • Generates true-to-life, full colour images.
  • Connects to your LIMS to store data and generate reports in Excel – no  transcription errors.
  • Provides accurate zone measurement around discs and MIC strips.
  • Features automatic comparison with EUCAST MIC breakpoint values.
  • Has free software upgrades to comply with EUCAST – no annual licence fee.
  • Provides fully traceable information for UKAS.

And don’t forget that in the UK, Don Whitley Scientific provides optional fully comprehensive maintenance and breakdown contracts to prolong the life of your investment.

Clostridium difficile studies can be done in a Whitley Workstation

Whitley Workstation used in Clostridium difficile study

The Whitley A35 Workstation has recently been used by a group at Monash University in a study relating to toxins affected by Clostridium difficile.

This very interesting research paper, entitled “CdtR Regulates TcdA and TcdB Production in Clostridium difficile“, was written by researchers at Monash University in Melbourne, Australia. The results from the study “establish CdtR as an important virulence regulator in two clinically important, epidemic strains of C. difficile, and further highlights the need to investigate regulatory mechanisms of important virulence factors in diverse strain backgrounds.”  The paper proves for the first time that “TcdA and TcdB production is linked to the production of CDT by a common regulatory mechanism”.

Click here to read the full paper

Whitley H35 Hypoxystation

Whitley H35 Hypoxystation used in tumour study

Researchers from Oxford and Stanford universities have been using an Whitley H35 Hypoxystation to look at how the hypoxic conditions of tumours repress DNA repair pathways that protect against genomic instability. Hypoxystation users Leszczynska et al describe the interaction of DNA damage kinase ATM with the ATM interactor ATMIN within hypoxia as well as the downstream consequences for DNA repair. An abstract from the article is posted below, as well as a link to the full article.

ATM activation is induced at severe hypoxia as a result of replication stress, and was thought to be dependent on the ATM interactor ATMIN, especially in the absence of DNA damage. Using ATMIN siRNA, ATM inhibitors, and knock-out cell lines, the authors were able to establish that ATMIN is not required for the activation of ATM in response to hypoxia-induced replication stress, and that ATMIN is repressed at hypoxia, an effect mediated by both p53 and HIF-1. The cells were exposed to varying degrees of hypoxia, from mild (2%) down to extreme (0.1%) in an Whitley H35 Hypoxystation by Don Whitley Scientific. The closed cell culture environment created in the Hypoxystation mimics physiological conditions with regard to oxygen, CO2, temperature, and humidity and enables cancer researchers to obtain a clearer picture of in vivo processes. qPCR analysis of cells in response to hypoxia and exposure to inhibitors of proteasomal degradation indicate that the repressive effect of hypoxia is due to inhibition of translation as opposed to transcription or altered stability of ATMIN.

Using ATMIN siRNA at various levels of hypoxia, the authors found that loss of ATMIN impairs base excision repair BER and increases sensitivity to DMA damaging agents such as methyl methanesulfonate MMS. Decreased ATMIN levels also decrease the expression of dynein light chain LC8-type 1 DYNLL1, again in a p53-dependent manner. Thus, the authors have found a new link between tumor hypoxia and ATMIN-regulated DYNLL1 expression. Loss of DYNLL1 in hypoxic tumors affects ciliogenesis, mitosis, cellular localization of proteins, to name a few, and justifies further research into the roles of ATMIN and DYNLL1 in cancer.

The full paper can be read here – Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1

finalised multiwell plate transfer tray

New Option Available – Multiwell Plate Transfer Tray

For Whitley Workstation customers who are working with multiwell plates, a new option has been developed to help you. If you have a DG250 or 85/95 sized Whitley Workstation, this new adapter for the porthole will enable you to transfer multiwell plates (also known as microwell or microplates) through the sleeve ports at the same time as you insert your arms.

This sturdy device pivots easily to allow smooth access of plates into the chamber environment.

Multiwell Plate Transfer Trays are easily attached and removed (with just one securing nut). If you are involved in a project that requires the incubation/manipulation of a large quantity of plates, you might choose to leave the tray fitted or for less frequent use, the trays can be fitted and removed as required.

Suitable for any cell/tissue culture and microbiology application. Sold in packs of 2. Product no. A07228

 
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New Building

Meintrup DWS Grand Opening

Don Whitley Scientific’s German subsidiary, Meintrup DWS Laborgeräte, recently celebrated the opening of their new headquarters.

Meintrup managing director Elke Hearn thanked all those who had attended and made the day so successful. Visitors from Don Whitley Scientific, UK, were also in attendance to contribute to the day’s celebrations. Speeches were given by managing director Paul Walton and founding chairman Don Whitley.

The new building is a two storey office with an adjacent warehouse, which will provide Meintrup DWS with the potential to grow and expand. It will enable them to build upon the fantastic work they already do with Don Whitley Scientific, being a key part of our international success. This work was praised as Don Whitley awarded Meintrup with the “Best Distributor” award, in recognition of their status as the current top selling distributor.

The full article and more details of the new office opening day can be found on the Meintrup DWS Laborgeräte website at: http://www.meintrup-dws.de/blog-de/meintrup-dws-laborgerate-feiert-eroffnung-in-herzlake/

 

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don and elke BCD_0133

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

micro logo

Microbiology International at Anaerobe 2016

Don Whitley Scientific’s US/Canadian distributor, Microbiology International, will be at this years Anaerobe Society of the Americas (ASA) Anaerobe meeting. This biennial conference will be hosted at the Sheraton Nashville Downtown Hotel in Nashville, Tennessee. The event is running between July 11-14.

Anaerobe 2016 has a program full of speakers, presentations and poster sessions as well some fantastic social activities. Presentations feature a range of topics relevant to an audience that will include researchers, clinicians and technicians and the social events include a pre congress mixer at a local blues club, a wine and cheese drinks reception and a congress dinner.

 

The Microbiology International stand will feature a Whitley A35 Anaerobic Workstation. This workstation offers a capacity of up to 600 90mm Petri dishes and features a touchscreen system, enabling users to stay in control of all parameters and conditions. The A35 is also available with instant access ports and a rapid cycle airlock system, these options can improve working methods in the lab.

Also available on the stand will be the publication: An Introduction to Clinical Anaerobic Bacteriology. This guide, published by Don Whitley Scientific, enables readers to isolate and identify commonly occurring, clinically important anaerobic bacteria. With consultation from some of the most experienced people in microbiology, this is one of the most up-to-date reference guides available for the modern clinical laboratory. There will be multiple copies available on the Microbiology International stand, so make sure you drop by while supplies last!

Other publications available on the stand are flyers which detail clinically relevant gram-negative and gram-positive anaerobes. Like the Introduction to Clinical Anaerobic Bacteriology, these should assist clinicians in identifying relevant anaerobes.

 

Introduction to Clinical Anaerobic Bacteriology

Introduction to Clinical Anaerobic Bacteriology

 

 

 

Gram postive anaerobes

Common Gram-Positive Anaerobes flyer

 

 

 

 

 

 

 

 

 

 

Visit Microbiology International at ASA Anaerobe Nashville 2016 – Sheraton Nashville Downtown Hotel, Nashville, Tennessee  July 11th-14th 2016

 

TCES logo

Tissue and Cell Engineering Society 2016

 Don Whitley Scientific recently exhibited at TCES 2016, the 16th annual meeting of the Tissue and Cell Engineering Society. The intention of these meetings is to bring together the UK research community in cell and tissue engineering with diversely themed sessions from a range of national and international speakers.

Held at the University College London Bloomsbury campus, the meeting featured an exciting programme of social events, with a pub crawl drinks reception to kick off proceedings. The event also featured a fantastic programme of speakers, oral presentations and poster abstracts. These sessions covered new approaches and attitudes to the field, such as the potential of mathematical and physical sciences to direct tissue engineering and regenerative medicine research, through to clinical and commercial applications.

Don Whitley Scientific were exhibiting two products which are relevant to this audience. The TC-3 Bioreactor is a simple and multipurpose cell culture bioreactor designed to provide mechanical stimulation to a variety of samples and tissues. This piece of equipment is adapted perfectly for cell culture work, providing an environment that replicates the conditions where tissues are located within the body and allowing the user to set different speeds and tensions for mechanical stimulation.

Also on the stand was the Whitley H35 Hypoxystation. This hypoxic workstation is specifically designed to create normoxic, hypoxic and anoxic conditions within a controlled and sustained environment. The H35 enables the manipulation and engineering of cells within these specific conditions, which are physiologically relevant to the environments found within the body where certain cells reside. Unique features and options make the H35 Hypoxystation a comfortable, convenient and reliable product for cell culture.

Paul on stand

Paul Harrison presiding over the Don Whitley Scientific trade stand